Late-Replicating Domains Have Higher Divergence and Diversity in Drosophila melanogaster
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چکیده
منابع مشابه
Late-replicating domains have higher divergence and diversity in Drosophila melanogaster.
Several reports from mammals indicate that an increase in the mutation rate in late-replicating regions may, in part, be responsible for the observed genomic heterogeneity in neutral substitution rates and levels of diversity, although the mechanisms for this remain poorly understood. Recent evidence also suggests that late replication is associated with high mutability in yeast. This then rais...
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Late-replicating domains (intercalary heterochromatin) in the Drosophila genome display a number of features suggesting their organization is quite unique. Typically, they are quite large and encompass clusters of functionally unrelated tissue-specific genes. They correspond to the topologically associating domains and conserved microsynteny blocks. Our study aims at exploring further details o...
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In D. melanogaster polytene chromosomes, intercalary heterochromatin (IH) appears as large dense bands scattered in euchromatin and comprises clusters of repressed genes. IH displays distinctly low gene density, indicative of their particular regulation. Genes embedded in IH replicate late in the S phase and become underreplicated. We asked whether localization and organization of these late-re...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2011
ISSN: 1537-1719,0737-4038
DOI: 10.1093/molbev/msr265